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These changes contribute to the gradual accumulation of cholesterol and subsequent deposition of gallstones

Liu S, Li R, Qian J et al (2020) Combination therapy of doxorubicin and quercetin on multidrug-resistant breast cancer and their sequential delivery by reduction-sensitive hyaluronic acid-based conjugate/ d--tocopheryl poly(ethylene glycol) 1000 succinate mixed micelles

Flavonoids for controlling starch digestion: Structural requirements for inhibiting human alpha-amylase

Therefore, clonidine therapy must always be tapered gradually over a minimum of 2 to 4 days (or weeks for higher doses), and any concurrent beta-blockers must be discontinued several days prior to beginning the taper (JAVADIN, 2025